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	Provedor de dados Biol. Res. (1) BJMBR (1) Autor Borges,D.R. (1) Kouyoumdjian,M. (1) Ma,Jiao (1) Mao,Meng (1) Nagaoka,M.R. (1) Tong,Yu (1) Yu,Dan (1) Mais... Palavra-chave Tissue-type plasminogen activator (2) Excitotoxicity (1) Hypoxia-ischemia (1) Inflammation (1) Kallikrein (1) Liver clearance (1) N-methyl-D-aspartic (1) Neuroserpin (1) Thrombin (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2012 (1) 2000 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Effect of neuroserpin in a neonatal hypoxic-ischemic injury model ex vivo Biol. Res. Ma,Jiao; Yu,Dan; Tong,Yu; Mao,Meng. Hypoxia-ischemia (HI) occurring in immature brains stimulates the expression of tissue-type plasminogen activator (tPA). Neuroserpin is a selected inhibitor of tPA in the central nerves system. However, the role that neuroserpin plays and the possible mechanisms involved during neonatal HI are poorly defined. In this study, an oxygen-glucose deprivation and reoxygenation (OGD/R) model was generated with cultured rat cortical neurons mimicking neonatal HI injury ex vivo, and an acute neuronal excitatory injury was induced by exposure to a high concentration of N-methyl-D-aspartic acid (NMDA). Cells received either neuroserpin or MK-801, an antagonist of the NMDA receptor, during OGD/R, and were incubated with or without neuroserpin after NMDA exposure. Cell... Tipo: Journal article Palavras-chave: Excitotoxicity; Hypoxia-ischemia; Neuroserpin; N-methyl-D-aspartic; Tissue-type plasminogen activator. Ano: 2012 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000400005 The hepatic clearance of recombinant tissue-type plasminogen activator decreases after an inflammatory stimulus BJMBR Nagaoka,M.R.; Kouyoumdjian,M.; Borges,D.R.. We have shown that tissue-type plasminogen activator (tPA) and plasma kallikrein share a common pathway for liver clearance and that the hepatic clearance rate of plasma kallikrein increases during the acute-phase (AP) response. We now report the clearance of tPA from the circulation and by the isolated, exsanguinated and in situ perfused rat liver during the AP response (48-h ex-turpentine treatment). For the sake of comparison, the hepatic clearance of a tissue kallikrein and thrombin was also studied. We verified that, in vivo, the clearance of 125I-tPA from the circulation of turpentine-treated rats (2.2 ± 0.2 ml/min, N = 7) decreases significantly (P = 0.016) when compared to normal rats (3.2 ± 0.3 ml/min, N = 6). The AP response does not modify the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Liver clearance; Inflammation; Kallikrein; Thrombin; Tissue-type plasminogen activator. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000100016 Registros recuperados: 2 Primeira ... 1 ... Última

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